TVO4 AND TVO5
TOV4 and TOV5 studies are two separate individual-randomized, double-blinded, placebo-controlled clinical trials of vitamin D, part of a long series of vitamin clinical trials among PLHIVs that MDH has been conducting in partnership with the Harvard T.H. Chan School of Public Health (HSPH) and Muhimbili University of Health and Allied Sciences (MUHAS).
TOV4 investigates the effect of vitamin D on mortality and TB incidence among HIV-infected adults; whereas TOV5 investigates effects of vitamin D on maternal HIV disease progression/death, infant small for gestational age and infant stunting at 12 months, among HIV-infected pregnant women; in Dar es Salaam region. By the end of 2018 both studies had completed enrollment and were at different stages of follow-up and analysis.